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Detailed analysis of CD8 responses in one such person who underwent treatment of acute infection followed by reexposure to HIV-1 through supervised treatment interruptions (STI) revealed recognition of only two cytotoxic T-lymphocyte (CTL) epitopes during symptomatic acute infection.
HIV-1-specific CD8 T-cell responses broadened significantly during subsequent exposure to the virus, ultimately targeting 27 distinct CTL epitopes, including 15 different CTL epitopes restricted by a single HLA class I allele (HLA-A3).
In both patients, the majority of the plasma clones were different at 2 or 3 amino acids from the majority of the proviral clones.Chromatograms were manually examined for the presence of double peaks indicative of two templates per sequencing reaction. Sequences were assembled using Codon Code Aligner, version 1.3.1, aligned using Clustal X, and the alignments were manually adjusted in Bioedit.Sequences were translated in Bioedit, and the mean number of amino acid differences between all provirus All independent clonal sequences obtained were included in the phylogenetic analysis, with the exception of sequences showing APOBEC3G/F-mediated hypermutation, which were removed.Images, videos and audio are available under their respective licenses.gene of ES which surprisingly was mostly due to synonymous mutations rather than non-synonymous mutation in targeted CTL epitopes.